Skip navigation

Doctors and scientists have long known that infants have fragile immune systems. They lack a robust defense system against invading pathogens, developing one as they age. In general, this suggested that the infant immune system simply needs time to get stronger. But new research indicates that infants’ immune response is actively being held down by immunosuppressive cells.Some precursors to red blood cells are marked by the protein CD71. Doctors at the Children’s Hospital in Cincinnati found that, in human umbilical cord blood and newborn mice, these cells make an enzyme called arginase-2 that actively inhibits the immune response. When they transferred immune cells from newborns into adult mice, they found that the cells themselves were fully functional and capable of ramping up an immune response in the adult environment. This shows that the key is how the immune cells are regulated, not whether the infant immune cells themselves are immature.

Posted via a mobile Android device.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: